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Researchers have found that the nucleolus, a small structure within the cell nucleus that helps make ribosomes, acts as a biological clock or "mortality timer."

As cells age, this nucleolus grows in size. When it becomes too large, the cell typically only divides about five more times before dying.

Key Findings:

Nucleolar size predicts cellular lifespan.

Enlarged nucleoli allow disruptive proteins inside, destabilizing ribosomal DNA (rDNA).

Controlling nucleolar size slows aging. In yeast, tethering rDNA to the nuclear membrane kept nucleoli small and delayed aging, similar to effects seen in caloric restriction.

Implications:

This research suggests that managing nucleolar size could one day offer a way to extend human healthspan and fight age-related decline.

Sources:

-Weill Cornell Medicine News
- Nature Cell Biology Study
- Coverage by major science outlets like ScienceAlert

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