Scientists at Delix Therapeutics and UC Davis have engineered a modified LSD compound called JRT by altering just two atoms. This innovation preserves the therapeutic potential of LSD—boosting mood and cognition—while eliminating the hallucinogenic effects.

It’s part of a new wave of “non-hallucinogenic psychedelics” that could revolutionize treatment for depression, schizophrenia, and PTSD by enhancing brain plasticity without the trip.

#LSDResearch #NeuroScience #MentalHealthInnovation #NonHallucinogenic #Psychoplastogens #DepressionTreatment

Male mice produce ultrasonic vocalizations—high-frequency chirps beyond the range of human hearing—as a courtship strategy to attract females.

These complex vocal sequences are triggered by the scent of female pheromones and are often described as “songs” due to their rhythmic and structured nature.

Far from being random noises, these vocalizations include variations in pitch, length, and pattern, resembling bird songs in their function.

A groundbreaking study by Dr. Timothy Holy and Zhongsheng Guo, published in PLOS Biology (2005), first demonstrated that male mice sing these ultrasonic songs in response to female cues.

The study revealed that the vocalizations were highly structured, with patterns of syllables that varied between individuals, suggesting they play a role in sexual selection.

Later research led by Joshua Neunuebel and colleagues, published in Nature Neuroscience (2015), provided further insight by showing that female mice not only hear these ultrasonic calls but also respond selectively to them.

Females showed preference for certain song structures, reinforcing the role of these vocalizations in mate choice.

These findings illuminate a hidden dimension of animal communication, revealing that even small mammals like mice possess complex, evolved behaviors for reproduction.

It also opens up new avenues for studying how brains process social sounds and how communication shapes mating strategies in the animal world.

Sources:

1. Holy, T. E., & Guo, Z. (2005). Ultrasonic songs of male mice. PLOS Biology, 3(12), e386.

2. Neunuebel, J. P., Taylor, A. L., Arthur, B. J., & Portfors, C. V. (2015). Female mice ultrasonically interact with males during courtship displays. Nature Neuroscience, 18, 1133–1139.