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In June 2025, the U.S. Food and Drug Administration (FDA) officially approved Yeztugo (lenacapavir) as the world’s first twice-yearly injection for HIV prevention (PrEP).

Developed by Gilead Sciences, this landmark drug offers long-term protection from HIV with just two subcutaneous shots per year.

The approval is based on extensive clinical trials under the PURPOSE 1 and 2 studies, which showed near-perfect efficacy—zero new infections in cisgender women and only two infections across a broader population of over 2,000 individuals.

This brings its protective rate to approximately 99.9%, making it the most effective and long-acting HIV prevention method available today.

Lenacapavir works by targeting the HIV capsid, a protein shell that encases the virus’s genetic material.

By inhibiting this capsid, the drug prevents HIV from replicating inside human cells.

Unlike daily oral PrEP options like Truvada or Descovy, Yeztugo is designed to overcome common adherence issues by requiring just one injection every six months. This simplifies prevention for at-risk

populations, especially those who struggle with daily medication routines.

While the approval is being hailed as a major victory in the global fight against HIV, access and affordability remain concerns.

The U.S. list price for a year’s supply is expected to be around $28,000, though Gilead has committed to providing generics to 120 low-income countries and producing up to 10 million doses by 2026.

Global health experts see this breakthrough as a turning point that could drastically reduce new HIV infections—if distribution is equitable and timely.

In summary, Yeztugo's approval represents a critical milestone in HIV prevention science, combining exceptional efficacy, convenience, and innovation.

It has the potential to reshape the future of HIV prevention—especially if healthcare systems can ensure widespread access to those most in need.

China’s Danyang–Kunshan Grand Bridge spans 164.8 kilometers (102.4 miles), making it the longest bridge in the world. Completed in 2010 and operational since 2011, the bridge plays a vital role in the Beijing–Shanghai High-Speed Railway, supporting bullet trains traveling up to 300 km/h.

Built over a complex network of lakes, rivers, rice paddies, and urban sprawl, the bridge required over 10,000 workers and four years to complete. It’s designed to withstand typhoons, magnitude-8 earthquakes, and even direct hits from naval vessels—cementing its place not just as a record-breaker, but a masterpiece of civil engineering.

#EngineeringMarvel #LongestBridge #ChineseInfrastructure #HighSpeedRail #CivilEngineering

Japan is building Dogen City — a revolutionary floating city designed to house 40,000 people while withstanding floods, tsunamis, and climate disasters. Built by startup N-Ark, this self-sufficient city is set to be completed by 2030 and could redefine how humanity lives with rising seas.

Its ring-shaped design includes renewable energy, vertical farming, smart medical care, and even an underwater data center. Most remarkably, it’s designed to float with the ocean current, absorbing shocks from natural disasters. Dogen City isn’t just science fiction—it’s a blueprint for the future of resilient living.

#DogenCity #JapanInnovation #FloatingCity #ClimateResilience #FutureCities

India has taken a giant leap in affordable space technology. Agnikul Cosmos, a Chennai-based startup, successfully launched its Agnibaan SOrTeD rocket—powered by the world’s first single-piece 3D-printed rocket engine. This innovation isn't just a technical milestone—it signals a new era of low-cost, high-impact aerospace development. Designed and built entirely in-house, the engine simplifies manufacturing and increases reliability by eliminating joints and welds.

This achievement also highlights India’s growing influence in the global private space sector. As nations race to commercialize space, Agnikul's model could enable smaller countries and private players to enter orbit without billion-dollar budgets. Backed by support from ISRO and IIT Madras, the startup has demonstrated that with the right mix of talent and technology, space access can be democratized—even from a university lab in Chennai.

#Agnikul #IndiaSpaceTech #3DPrintedRocket #SpaceInnovation #AffordableAerospace #ISRO #StartupIndia #TechRevolution