Scientists at the University of Sunderland, led by Dr. Maria Teresa Borrello, have developed two experimental drugs—DR-3 and FDR2—that target the enzyme HDAC6.

These drugs have shown promise in halting or reversing liver fibrosis, a condition characterized by the accumulation of scar tissue in the liver.

Research Overview

The research, published in The FEBS Journal, focuses on the role of HDAC6 in liver fibrosis.

HDAC6 is involved in regulating inflammation and the activation of hepatic stellate cells, which are responsible for producing collagen and contributing to scar tissue formation.

By inhibiting HDAC6, the experimental drugs aim to reduce inflammation and prevent the activation of these stellate cells, thereby mitigating fibrosis progression.

Laboratory Findings

In laboratory settings, the HDAC6 inhibitors DR-3 and FDR2 demonstrated high selectivity for HDAC6 over other histone deacetylases.

They effectively reduced markers of hepatic stellate cell activation and fibrogenic gene expression.

Additionally, these compounds increased acetylation of α-tubulin and suppressed TGF-β1-induced SMAD signaling, which are key pathways in fibrosis development.

Ex Vivo Human Liver Models

The efficacy of DR-3 and FDR2 was further validated using human precision-cut liver slices (hPCLS), an ex vivo model that closely mimics human liver tissue.

Treatment with these inhibitors resulted in reduced fibrogenic protein levels and collagen deposition, indicating their potential to reverse existing fibrosis.

Importantly, these effects were achieved without significant toxicity to the liver tissue.

Clinical Implications

The British Liver Trust has welcomed these findings, highlighting their potential to transform care for the UK's estimated two million liver fibrosis patients, many of whom are diagnosed at advanced stages of the disease.

While these results are promising, the drugs are still in the experimental phase and have not yet undergone human clinical trials. Nevertheless, they offer a targeted therapeutic approach that could eventually become a lifesaving treatment worldwide.

In a monumental leap forward, scientists have used CRISPR-Cas9 gene editing to successfully remove HIV DNA from infected human immune cells in laboratory and animal models. The technique, pioneered by researchers at Temple University and Excision BioTherapeutics, forms the basis of a new treatment called EBT-101, which specifically targets and cuts out integrated HIV genetic material hidden in T-cells—something traditional therapies cannot do.

While still in early clinical trials, the results are promising. The treatment was found to be safe and well-tolerated, though some patients saw a viral rebound after stopping antiretroviral therapy, indicating further refinement is needed. In parallel, scientists in the Netherlands demonstrated similar success using CRISPR to delete HIV from lab-grown cells. Although not a complete cure yet, this innovation paves the way for a one-time gene therapy that could revolutionize HIV treatment and bring us closer to eliminating the virus entirely.

#CRISPR #HIVResearch #GeneEditing #MedicalBreakthrough
#FutureOfMedicine

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Researchers at Rice University, in collaboration with Texas A&M University and MD Anderson Cancer Center, have developed a groundbreaking cancer treatment that uses "molecular jackhammers" to destroy cancer cells using near-infrared light.

These jackhammers are specially engineered molecules—based on aminocyanine dyes commonly used in imaging—that bind to cancer cells.

When exposed to near-infrared (NIR) light, the molecules begin to vibrate intensely through a process called vibronic-driven action (VDA).

This mechanical vibration physically tears apart cancer cell membranes, effectively killing the cells without relying on heat or chemicals.

Unlike traditional treatments such as chemotherapy or radiation, this method offers a non-toxic and highly selective approach.

The molecules remain inactive until NIR light is applied, which means they only destroy the targeted cancer cells while sparing healthy tissue.

Because infrared light can penetrate up to 10 centimeters into the body, this technique can potentially treat tumors deep within internal organs—offering a new frontier for non-invasive cancer therapy.

Lab experiments have shown striking success: the vibrating molecules destroyed up to 99% of melanoma cancer cells in vitro.

In animal models, mice treated with the method experienced tumor shrinkage, and half of the mice became cancer-free. Since aminocyanine dyes are already FDA-approved for medical imaging, researchers believe this innovation could reach clinical trials within the next 5–7 years.

This technique stands out because it uses mechanical force—not heat, drugs, or radiation—to kill cancer cells, which reduces side effects and may limit the risk of resistance.

With further development, this method could transform cancer treatment by offering a precise, controllable, and less harmful therapy for various cancer types.

Prima mea participare la Campionatul Național s-a încheiat cu emoții, recunoștință și împlinire.
Locul 1 First Timers, Locul 1 Bikini, Locul 1 Fit Model Grand Prix, Locul 2 Bikini Grand Prix.
Și, poate cel mai mare cadou: am fost selectată în Lotul Național. Un pas uriaș pentru mine.

Vreau să mulțumesc din inimă antrenorului meu @poppaulalexandru92 pentru toată încrederea, îndrumarea, susținerea si profesionalism.
Mulțumesc iubitului meu pentru sprijinul pe care mi l-a oferit zi de zi, pentru răbdare și iubire.
Mulțumesc @andreeasfiriac8 pentru pașii de grație care au completat antrenamentele cu eleganță.
Mulțumesc prietenilor mei – pentru fiecare mesaj, gând bun și pentru că ați fost alături de mine, chiar și de la distanță.
Mulțumesc @titiantrenor dar și @frcf_culturismsifitnessromania pentru organizare si oportunitate.

#frcf #bikini #fitmodels #firsttimers #begging CATERINA DAN IG:caterina_dan