Rui Takanashi 小鳥遊るい

My cat is in this photo

Dr House..

I was asked by The Atlantic to paint a portrait of James Joyce and it got published today

最強のふたりが夢の競演

それにしてもビジュアルが強すぎる

GARGANTUAN PHILLY MAC & CHEESE DEEP DISH

Ingredients:
1 deep-dish crust
1 cup thin-sliced Philly steak or ribeye, cooked
½ cup sautéed onions & peppers
2 cups creamy mac & cheese
1 cup shredded provolone or mozzarella
Optional: garlic butter for brushing

Instructions:
1⃣ Spread mac & cheese into crust base.
2⃣ Layer on steak, onions, and peppers.
3⃣ Top with shredded cheese.
4⃣ Bake at 375°F (190°C) for 25–30 min until bubbling and golden.
5⃣ Brush crust with garlic butter if desired. Dig into this molten Philly mash-up!

Prep: 15 min | Cook: 30 min | Total: 45 min | Serves: 4

Researchers at Singapore's A*STAR Genome Institute have developed a new AI-based method called Fragle that can detect even the tiniest traces of cancer in a patient's blood.

Unlike traditional liquid biopsy techniques that require expensive, targeted gene sequencing, Fragle uses a low-cost approach that analyzes the fragment sizes of cell-free DNA—a subtle clue that can indicate the presence of tumor DNA (ctDNA).

Cancer-derived DNA fragments tend to be shorter and follow distinct patterns, which Fragle can detect using shallow whole-genome sequencing and machine learning.

This technique stands out because it's fast, highly sensitive, and affordable, costing less than SGD $50 per test compared to traditional methods that often exceed SGD $1,000.

It also doesn’t depend on knowing the specific mutations of a patient’s cancer, making it more universally applicable across cancer types.

Fragle could revolutionize cancer care by enabling frequent, non-invasive monitoring of cancer progression, recurrence, or response to treatment.

However, it still requires extensive clinical validation before it can be widely adopted in real-world healthcare settings.