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It's mind-boggling that in 2026, GTA VI isn't releasing on PC at launch. A total old school ideology from Rockstar Games.

Scientists at the University of Sunderland, led by Dr. Maria Teresa Borrello, have developed two experimental drugs—DR-3 and FDR2—that target the enzyme HDAC6.

These drugs have shown promise in halting or reversing liver fibrosis, a condition characterized by the accumulation of scar tissue in the liver.

Research Overview

The research, published in The FEBS Journal, focuses on the role of HDAC6 in liver fibrosis.

HDAC6 is involved in regulating inflammation and the activation of hepatic stellate cells, which are responsible for producing collagen and contributing to scar tissue formation.

By inhibiting HDAC6, the experimental drugs aim to reduce inflammation and prevent the activation of these stellate cells, thereby mitigating fibrosis progression.

Laboratory Findings

In laboratory settings, the HDAC6 inhibitors DR-3 and FDR2 demonstrated high selectivity for HDAC6 over other histone deacetylases.

They effectively reduced markers of hepatic stellate cell activation and fibrogenic gene expression.

Additionally, these compounds increased acetylation of α-tubulin and suppressed TGF-β1-induced SMAD signaling, which are key pathways in fibrosis development.

Ex Vivo Human Liver Models

The efficacy of DR-3 and FDR2 was further validated using human precision-cut liver slices (hPCLS), an ex vivo model that closely mimics human liver tissue.

Treatment with these inhibitors resulted in reduced fibrogenic protein levels and collagen deposition, indicating their potential to reverse existing fibrosis.

Importantly, these effects were achieved without significant toxicity to the liver tissue.

Clinical Implications

The British Liver Trust has welcomed these findings, highlighting their potential to transform care for the UK's estimated two million liver fibrosis patients, many of whom are diagnosed at advanced stages of the disease.

While these results are promising, the drugs are still in the experimental phase and have not yet undergone human clinical trials. Nevertheless, they offer a targeted therapeutic approach that could eventually become a lifesaving treatment worldwide.

Spanish Zarzuela de Mariscos – Catalan Seafood Medley

A luxurious seafood stew from Catalonia, Zarzuela is made with a medley of shellfish and fish in a saffron-tomato-white wine sauce, often served at special occasions.

Ingredients (Serves 4):

* 200g shrimp
* 200g mussels
* 200g clams
* 300g firm white fish (hake, monkfish)
* 1 onion, chopped
* 2 garlic cloves, minced
* 2 tomatoes, peeled and chopped
* 100ml white wine
* 1 pinch saffron threads
* Olive oil, salt, pepper, parsley

Instructions:

1. Sauté onion and garlic in olive oil. Add tomatoes and saffron, cook until thickened.
2. Pour in white wine and simmer.
3. Add fish, then mussels, clams, and shrimp. Cover and steam until shellfish open and fish is cooked.
4. Season and garnish with parsley. Serve with toasted bread.

Catalan Tip:
For extra richness, blend a paste of almonds and garlic (picada) and stir in before serving.

Looking for a delicious low-carb twist on a classic dish? This Keto Chicken Fried Steak is crispy, savory, and oh-so-satisfying!

Ingredients:
- 1 pound cube steak
- 1 cup almond flour
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- 1 teaspoon paprika
- 1 teaspoon salt
- 1/2 teaspoon black pepper
- 2 large eggs
- 1/4 cup heavy cream
- 1/4 cup pork rinds, crushed (optional, for extra crunch)
- 1/4 cup coconut oil or avocado oil (for frying)

Directions:
1. Start by preheating your oven to 200°F. This way, you can keep those beautifully cooked steaks warm while you finish frying.
2. In a shallow bowl, mix together the almond flour, garlic powder, onion powder, paprika, salt, and black pepper. Give it a good stir to combine all those zesty flavors.
3. In another bowl, whisk the eggs and heavy cream together until they're well blended and ready for coating.
4. Time to dip! Take each cube steak and first immerse it in the egg mixture, letting any excess drip off, then coat it thoroughly in the almond flour mixture. If you’re feeling adventurous, press it into the crushed pork rinds for an extra crunch.
5. Heat your choice of coconut oil or avocado oil in a large skillet over medium-high heat. You want that oil nice and hot!
6. Carefully add the coated cube steaks to the skillet. Fry them for about 3-4 minutes on each side until they turn a gorgeous golden brown and are cooked through.
7. Once cooked, transfer the steaks to a baking sheet and pop them in the oven to keep warm while you finish the rest.
8. Serve these hot, and for an extra treat, why not pair with a keto-friendly gravy or a side of steamed veggies?

Nutritional Values (per serving):
- Serving Size: 1 steak
- Calories: 420
- Protein: 35g
- Fat: 30g
- Carbohydrates: 8g
- Fiber: 4g
- Net Carbs: 4g

Enjoy your keto-friendly feast! #KetoRecipes #LowCarb #EatClean #ChickenFriedSteak #HealthyEating