5 years drug free
5 years drug free
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Researchers at Duke University identified ALDH4A1, a metabolic enzyme that plays a critical role in cellular energy production and cancer suppression.
Key points:
ALDH4A1 stabilizes a protein complex that imports pyruvate into mitochondria, fueling healthy cell function.
Loss of ALDH4A1 leads to the Warburg effect, where cancer cells rely on inefficient glycolysis.
Tumors often show reduced ALDH4A1, and restoring its activity slows tumor growth.
The study suggests ALDH4A1 could be a therapeutic target to cut off energy supply to cancer cells while preserving normal ones.Researchers at Duke University identified ALDH4A1, a metabolic enzyme that plays a critical role in cellular energy production and cancer suppression. Key points: ALDH4A1 stabilizes a protein complex that imports pyruvate into mitochondria, fueling healthy cell function. Loss of ALDH4A1 leads to the Warburg effect, where cancer cells rely on inefficient glycolysis. Tumors often show reduced ALDH4A1, and restoring its activity slows tumor growth. The study suggests ALDH4A1 could be a therapeutic target to cut off energy supply to cancer cells while preserving normal ones.
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COLOSSAL TURKEY & BRIE HOLIDAY MELT
Ingredients:
1/2 lb sliced roasted turkey
4 oz brie cheese, sliced
4 slices thick sourdough or rustic bread
1/4 cup cranberry sauce
Handful of arugula or spinach
Butter for grilling
Instructions:
1️⃣ Butter bread slices and layer turkey, brie, cranberry sauce, and greens.
2️⃣ Grill sandwich in skillet or press until bread is golden and cheese is melty.
3️⃣ Slice and serve warm — holiday flavors in every bite!
Prep: 10 min | Cook: 10 min | Total: 20 min | Serves: 2COLOSSAL TURKEY & BRIE HOLIDAY MELT 🦃🧀🍞 Ingredients: 🦃 1/2 lb sliced roasted turkey 🧀 4 oz brie cheese, sliced 🍞 4 slices thick sourdough or rustic bread 🍒 1/4 cup cranberry sauce 🌿 Handful of arugula or spinach 🧈 Butter for grilling Instructions: 1️⃣ Butter bread slices and layer turkey, brie, cranberry sauce, and greens. 2️⃣ Grill sandwich in skillet or press until bread is golden and cheese is melty. 3️⃣ Slice and serve warm — holiday flavors in every bite! 🔥 Prep: 10 min | Cook: 10 min | Total: 20 min | Serves: 2
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Beef and Guinness Stew
Hearty Slow-Cooked Beef and Guinness Stout Stew
Ingredients:
2 pounds beef chuck, cut into 1-inch cubes
Salt and black pepper to taste
3 tablespoons all-purpose flour
2 tablespoons vegetable oil
1 large onion, chopped
3 cloves garlic, minced
3 carrots, sliced
2 stalks celery, sliced
2 cups Guinness stout beer
2 cups beef broth
2 tablespoons tomato paste
1 tablespoon Worcestershire sauce
2 teaspoons dried thyme
2 bay leaves
1 cup frozen peas
Fresh parsley, chopped (for garnish)
Directions:
Season beef cubes with salt and pepper, then toss in flour until coated.
Heat vegetable oil in a large heavy-bottomed pot over medium-high heat. Brown the beef in batches until deep golden on all sides. Remove and set aside.
In the same pot, sauté onions until translucent, about 5 minutes. Add garlic, carrots, and celery, cooking for another 3 minutes.
Stir in tomato paste and cook for 1 minute.
Pour in the Guinness and beef broth, scraping up browned bits from the bottom of the pot.
Return beef to the pot, add Worcestershire sauce, thyme, and bay leaves. Bring to a boil, then reduce heat to low, cover, and simmer for 2 to 2½ hours until beef is tender.
Stir in frozen peas and cook for another 5 minutes. Remove bay leaves.
Adjust seasoning with salt and pepper. Garnish with fresh parsley before serving.
Prep Time: 20 minutes | Cooking Time: 2 hours 30 minutes | Total Time: 2 hours 50 minutes
Kcal: 420 kcal (per serving) | Servings: 6 servings
#beefstew #guinnessstew #slowcookedmeals #comfortfood #irishrecipes #heartydinners #stewseason #classicbeefstew #meatloverrecipes #slowcookermeals #weekendcooking #beefrecipes #guinnessbeer #homemadestew #dinnertimeideas #onepotmeals #comfortfoodlover #irishcuisine #richflavors #warmandcozy
Cozy up with a bowl of this hearty Beef and Guinness Stew—slow-cooked to perfection with tender beef, rich stout, and savory veggies! Perfect for chilly nights.Beef and Guinness Stew Hearty Slow-Cooked Beef and Guinness Stout Stew Ingredients: 2 pounds beef chuck, cut into 1-inch cubes Salt and black pepper to taste 3 tablespoons all-purpose flour 2 tablespoons vegetable oil 1 large onion, chopped 3 cloves garlic, minced 3 carrots, sliced 2 stalks celery, sliced 2 cups Guinness stout beer 2 cups beef broth 2 tablespoons tomato paste 1 tablespoon Worcestershire sauce 2 teaspoons dried thyme 2 bay leaves 1 cup frozen peas Fresh parsley, chopped (for garnish) Directions: Season beef cubes with salt and pepper, then toss in flour until coated. Heat vegetable oil in a large heavy-bottomed pot over medium-high heat. Brown the beef in batches until deep golden on all sides. Remove and set aside. In the same pot, sauté onions until translucent, about 5 minutes. Add garlic, carrots, and celery, cooking for another 3 minutes. Stir in tomato paste and cook for 1 minute. Pour in the Guinness and beef broth, scraping up browned bits from the bottom of the pot. Return beef to the pot, add Worcestershire sauce, thyme, and bay leaves. Bring to a boil, then reduce heat to low, cover, and simmer for 2 to 2½ hours until beef is tender. Stir in frozen peas and cook for another 5 minutes. Remove bay leaves. Adjust seasoning with salt and pepper. Garnish with fresh parsley before serving. Prep Time: 20 minutes | Cooking Time: 2 hours 30 minutes | Total Time: 2 hours 50 minutes Kcal: 420 kcal (per serving) | Servings: 6 servings #beefstew #guinnessstew #slowcookedmeals #comfortfood #irishrecipes #heartydinners #stewseason #classicbeefstew #meatloverrecipes #slowcookermeals #weekendcooking #beefrecipes #guinnessbeer #homemadestew #dinnertimeideas #onepotmeals #comfortfoodlover #irishcuisine #richflavors #warmandcozy 🍲🍺 Cozy up with a bowl of this hearty Beef and Guinness Stew—slow-cooked to perfection with tender beef, rich stout, and savory veggies! Perfect for chilly nights. 🥕🥩
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